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I have been a victim of psoriasis for the last seven years. I came to know about this drug from a skin specialist in the year 2004. Prior to this I was covered up to 75% but when I took this it vanished after taking a mere 30 mg. It recurred in year 2005. Since then I am taking it frequently, as I did not find any other alternative to fight this skin disorder. As far as my personal experience is concerned, I didn't have any side effect.
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I am female, 41, have been taking methotrexate for 2 months now. I was crippled, my hands fingers wrists ankles balls of my feet knees shoulders arms even my jaw. I could barely walk I couldn't unscrew lids, peel potatoes, do everyday chores people take for granted. My rheumatoid factor was 1380. After 1 month no change hopefully my 2nd reading it will come down. Anyway after 1 month on the medication my joint pains has disappeared thanks to Methotrexate. I take 10mg once weekly with folic acid next day. Worked for me. YAY!

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Jensen, M S Hansen, K Hørslev-Petersen, L Hyldstrup, B Abrahamsen, B Langdahl, B Zerahn, J Pødenphant, K Stengaard-Petersen, P Junker, M Østergaard, T Lottenburger, T Ellingsen, L S Andersen, I Hansen, H Skjødt, J K Pedersen, U B Lauridsen, A J Svendsen, U Tarp, H Lindegaard, Anne Grethe Jurik, Aage Vestergaard, M L Hetland, Periarticular and generalised bone loss in patients with early rheumatoid arthritis: influence of alendronate and intra-articular glucocorticoid treatment.

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Methotrexate is also used along with rest, physical therapy, and sometimes other medications to treat severe active rheumatoid arthritis (RA; a condition in which the body attacks its own joints, causing pain, swelling, and loss of function) that cannot be controlled by certain other medications.

Many people find that acupuncture helps relieve pain and disability due to arthritis; several studies have found benefit from the procedure.

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