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Leucovorin in the Adjuvant Treatment of Colon Cancer (better known as MOSAIC) trial showed that adding oxaliplatin to infused fluorouracil plus leucovorin provides a 23 percent reduction in the risk of recurrence, which is a significant and clinically meaningful benefit.

T-DM1, a novel antibody-drug conjugate, is highly effective against primary HER2 overexpressing uterine serous carcinoma in vitro and in vivo.

It would be a mistake to generalize too much about attempts to locate these tumors.

Therefore, the combination of pertuzumab with trastuzumab and chemotherapy has the potential to improve survival outcomes in patients with HER2-positive aGC compared with trastuzumab and chemotherapy alone.

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Prognostic factors and long-term results after surgery for gallbladder carcinoma: a retrospective study of 127 patients.

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Epidemiologic studies have linked increased risk of colorectal cancer with a diet high in red meat and animal fat, low-fiber diets, and low overall intake of fruits and vegetables.

Upon enrollment in the IVC trial he received 3-week cycles of irinotecan, bevacizumab and capecitabine.

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Two additional patients died from events that were later determined to be related to disease progression and central nervous system metastases, respectively.

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All DPYD sequence variants identified by DHPLC were confirmed by DNA sequencing using a dideoxynucleotide chain termination method (Big Dye Kit; Applied Biosystems, Foster City, CA) and capillary electrophoresis on an ABI 310 Automated DNA Sequencer (Applied Biosystems, Foster City, CA).

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Cox regression model, using data from all 408 enrolled patients, evaluated the effects of treatment group along with baseline disease history and prognostic factors, described in Patients and Methods, on OS.

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In the present case, the patient had chronic pancreatitis with large fibrotic areas and severe atrophy of the pancreatic parenchyma, without atherosclerosis, after five chemotherapy cycles of capecitabine-based regimen.

Response to Preoperative Chemotherapy Predicts Survival in Patients Undergoing Hepatectomy for Liver Metastases from Gastric and Esophageal Cancer.

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Acute electrocardiographic findings suggestive of ischemia were found in some cases at initial presentation, and 1 patient had troponin elevation consistent with an acute ST-segment elevation myocardial infarction.

The CA 19-9 marker, a Lewis blood group-related mucin, is frequently elevated in pancreatic cancer, but its use as a sole agent in the screening for or diagnosis of cancer of the pancreas is not presently a fully accepted practice.

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You will need frequent blood tests to check your liver function.

Using an innovative approach to identify a cancer's genetic vulnerabilities by more swiftly analyzing human tumors transplanted into mice, researchers have identified a new potential target for pancreatic cancer treatment, published online in Cell Reports.

Overexpression of Notch 1 signaling associates with the tumorigenesis of gastric adenorna and intestinal type of gastric cancer.

Dosimetry studies with 177Lu-DOTATATE as well as the limited side effects with additional cycles of 177Lu-DOTATATE suggest that more cycles of 177Lu-DOTATATE can be safely given.

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Treatment was extremely well tolerated, with grade 3 and 4 adverse events (mainly, diarrhea, hand-foot syndrome, and thrombocytopenia) observed in only 6 patients (12%).

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The primary goal of the study was to investigate whether capecitabine and oxaliplatin are at least as effective as fluorouracil and cisplatin, respectively, in terms of overall survival.

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Twelve patients received no prior medical or surgical lines of therapy.

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Capecitabine in combination with docetaxel was assessed in an open-label, multicenter, randomized trial in 75 centers in Europe, North America, South America, Asia, and Australia.

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Phase 2 Study to Evaluate the Safety and Efficacy of SU11248 in Patients with Unresectable Neuroendocrine Tumors.

Total carboplatin dose calculation based on serum creatinine levels measured by isotope dilution mass spectrometry using the Calvert formula may result in overestimation of the GFR in some patients with normal renal function, and therefore increased drug-related toxicity.

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There are no adequate and well controlled studies of Capecitabine in pregnant women.

The China Food and Drug Administration approved the use of capecitabine in patients with metastatic colorectal cancer (mCRC) in 2004.

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Groups were well-balanced with respect to age, histologic findings, performance status, previous use or non-use of a radio-sensitizing platinum agent, and disease status.

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There is insufficient safety data on the use of azathioprine or 6-MP during breastfeeding; therefore, breastfeeding is not recommended while taking these medications.

CEACAM5-targeted therapy of human colonic and pancreatic cancer xenografts with potent labetuzumab-SN-38 immunoconjugates.

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Flow cytometry analysis for cell surface expression of CD11b shows time- and dose-dependent upregulation of the marker CD11b in MLL-rearranged leukemia cells treated with EPZ-5676 and Cytarabine(Ara-C) as single agents and in combination.

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More recent data has led to further understanding of each anti-tumor effect pertuzumab has on cancerous cell lines.

Phase III trial assessing bevacizumab in stages II and III carcinoma of the colon: results of NSABP protocol C-08.

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Treatment of locally unresectable carcinoma of the pancreas: comparison of combined-modality therapy (chemotherapy plus radiotherapy) to chemotherapy alone.

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Despite some indication of maintained quality of life when higher doses of the vitamin were infused, we did not observe anti-cancer effects when IVC was used as the sole treatment for advanced incurable cancer that had previously failed all other treatments.

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The immune system and response to HER2-targeted treatment in breast cancer.

Bang YJ, Van Cutsem E, Feyereislova A, Chung HC, Shen L, Sawaki A, Lordick F, Ohtsu A, Omuro Y, Satoh T, Aprile G, Kulikov E, Hill J, Lehle M, Rüschoff J, Kang YK (2010) Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial.

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TME): results and experience with the first 20 patients undergoing curative-intent rectal cancer surgery at a single institution.

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The safety of adjuvant capecitabine was greater, with a low rate of treatment-related mortality (0.

The NCCN recommends FOLFIRINOX as a preferred first-line treatment for patients with metastatic or locally advanced unresectable disease with good performance status.

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Neoptolemos discusses the results of the trial as well as the next steps in pancreatic cancer research.

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Malignant melanoma: effects of a brief, structured psychiatric intervention on survival and recurrence at 10-year follow-up.

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Early reports from sacituzumab govitecan (IMMU-132) suggest that there may be differences in the incidence of neutropenia in different patient groups, with 30% of triple negative breast cancer patients, 24% of gastrointestinal cancer patients and 18% of lung cancer patients reporting neutropenia.

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The ERBB2 gene has been extensively studied as a target for both chemotherapy and immunotherapy.

Three patients experienced notably unpleasant side effects: nausea and occasional vomiting during the IVC infusion (patient 4); thirst and an unpleasant fluttering sensation in the upper abdomen during the IVC infusion and a mentally hazy feeling the day after it (patient 7); chills, thirst, headache, and a rumbling feeling during the IVC infusion, as well as increased leg edema for a few days after each infusion (patient 10).

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In a large confirmatory intergroup trial, 5-FU-levamisole prolonged DFS and OS in patients with stage III colon cancer compared with patients who received no treatment after surgery.

The percentage of patients requiring dose reductions due to adverse reactions was 65% in the combination arm and 36% in the monotherapy arm.

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Exercise caution when patients with mild to moderate hepatic dysfunction due to liver metastases are treated with Xeloda.

At baseline and 12 weeks, rates of compliance in responding to the quality-of-life questionnaire were 96% and 70%, respectively.

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