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Does estradiol cause fatigue? High levels of estrogen may put you at higher risk of blood clots and stroke. Estrogen dominance may also increase your chances of thyroid dysfunction. This can cause symptoms such as fatigue and weight changes.
What are the side effects of taking progesterone? Common side effects may include: drowsiness, dizziness; breast pain; mood changes; headache; constipation, diarrhea, heartburn; bloating, swelling in your hands or feet; joint pain; hot flashes; or.